Agmon Ilana
Institute for Advanced Studies in Theoretical Chemistry, Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Haifa, Israel.
Fritz Haber Research Center for Molecular Dynamics, Hebrew University, Jerusalem, Israel.
FEBS Lett. 2017 Oct;591(20):3252-3258. doi: 10.1002/1873-3468.12781. Epub 2017 Sep 11.
A feasible scenario for the emergence of life requires the spontaneous materialization and sustainability of a proto-ribosome that could have catalysed the formation of the first peptides. Models of proto-ribosomes were derived from the ribosomal Peptidyl Transferase Centre (PTC) region, but the poor prebiotic copying abilities give rise to the question of their mode of replication. Here, complementarity is demonstrated in bacterial ribosomes, between nucleotides that constitute the two halves of the PTC cavity. The complementarity corroborates the dimeric nature of the proto-ribosome and is likely to underlie the symmetry of the PTC region. Furthermore, it indicates a simple and efficient replication mode; the strand of each monomer could have acted as a template for the synthesis of its counterpart, forming a self-replicating ribozyme.
生命出现的一个可行场景需要原核糖体的自发形成和可持续性，原核糖体可能催化了第一批肽的形成。原核糖体模型源自核糖体肽基转移酶中心（PTC）区域，但较差的前生物复制能力引发了其复制方式的问题。在这里，在构成PTC腔两半的核苷酸之间，细菌核糖体中表现出了互补性。这种互补性证实了原核糖体的二聚体性质，并且可能是PTC区域对称性的基础。此外，它表明了一种简单而有效的复制模式；每个单体的链可以作为其对应物合成的模板，形成一种自我复制的核酶。
