Aquino-Parsons C, Green A, Minchinton A I
Department of Radiation Oncology, British Columbia Cancer Agency and British Columbia Cancer Research Centre, 600 West 10th Ave., Vancouver, BC V5Z 4E6, Canada.
Radiother Oncol. 2000 Oct;57(1):45-51. doi: 10.1016/s0167-8140(00)00277-2.
To assess the effect of inhalation of various high oxygen content gases (HOCG) with different carbon dioxide concentrations on the tumour oxygen tension in patients with primary gynaecological malignancies.
Tumour oxygen tension was assessed on two protocols in those patients with locally advanced visible or palpable primary gynaecological malignancies. Patients were assessed initially while breathing room air (R/A). After 4 min of inhaling the first HOCG, a second assessment of the oxygen tension within the tumour was made. After a 10 min rest period while inhaling R/A, the second HOCG was administered for 4 min after which the third set of measurements were obtained. Protocol A involved assessing the tumour oxygen tension in 12 patients while breathing R/A, 100% oxygen (O(2)) and 5% carbogen (95% O(2), 5% CO(2)). For protocol B, tumour oxygen tension assessments of 13 patients while breathing R/A, 2.5% carbogen (97.5% O(2), 2.5% CO(2)), and 5% carbogen. Median pO(2) and percentage of values </=2.5 mmHg were assessed.
Regarding protocol A, the median of the median pO(2) values increased from 5 mmHg when breathing R/A to 47 mmHg for 100% O(2) and to 105 mmHg for 5% carbogen inhalation. The median of the percentage of values </=2. 5 mmHg decreased: 17% for R/A vs. 16% for 100% O(2) (P=ns) vs. 0% for 5% carbogen (P=0.015). In protocol B, the median of the median pO(2) values increased from 3 mmHg when breathing R/A to 73 mmHg when inhaling 2.5% carbogen and to 72 mmHg for 5% carbogen inhalation. The median of the percentage of values </=2.5 mmHg decreased with both carbogen mixtures compared with room air: 42% for R/A vs. 0% for 2.5% carbogen (P=0.05) and 3% for 5% carbogen (P=0.015). No statistically significant difference in this parameter was found between the two carbogen concentrations.
Oxygen tension as measured with an Eppendorf pO(2) histograph, increased with inhalation of the oxygen and carbon dioxide gas mixtures tested. While 100% oxygen inhalation increased the median pO(2) compared with R/A a significantly greater increase in oxygen tension was seen with inhalation of either carbogen gas mixture. Pure oxygen inhalation did not decrease the percentage of values </=2.5 mmHg whereas inhalation of either 2.5 and 5% carbogen gas resulted in a significant decrease in this parameter. Both carbogen concentrations appear equal at increasing the oxygen tension in primary gynaecological tumours as measured with the Eppendorf pO(2) histograph.
评估吸入不同二氧化碳浓度的各种高氧含量气体（HOCG）对原发性妇科恶性肿瘤患者肿瘤氧张力的影响。
对患有局部晚期、可见或可触及的原发性妇科恶性肿瘤的患者，按照两种方案评估肿瘤氧张力。患者最初在呼吸室内空气（R/A）时接受评估。在吸入第一种HOCG 4分钟后，对肿瘤内的氧张力进行第二次评估。在吸入R/A的10分钟休息期后，给予第二种HOCG 4分钟，之后进行第三组测量。方案A包括评估12例患者在呼吸R/A、100%氧气（O₂）和5%卡波金（95% O₂，5% CO₂）时的肿瘤氧张力。对于方案B，评估13例患者在呼吸R/A、2.5%卡波金（97.5% O₂，2.5% CO₂）和5%卡波金时的肿瘤氧张力。评估中位pO₂以及≤2.5 mmHg值的百分比。
关于方案A，中位pO₂值的中位数从呼吸R/A时的5 mmHg增加到吸入100% O₂时的47 mmHg以及吸入5%卡波金时的105 mmHg。≤2.5 mmHg值的百分比的中位数降低：R/A时为17%，100% O₂时为16%（P = 无统计学意义），5%卡波金时为0%（P = 0.015）。在方案B中，中位pO₂值的中位数从呼吸R/A时的3 mmHg增加到吸入2.5%卡波金时的73 mmHg以及吸入5%卡波金时的72 mmHg。与室内空气相比，两种卡波金混合物吸入时≤2.5 mmHg值的百分比的中位数均降低：R/A时为42%，2.5%卡波金时为0%（P = 0.05），5%卡波金时为3%（P = 0.015）。两种卡波金浓度在该参数上未发现统计学显著差异。
用Eppendorf pO₂组织氧张力仪测量的氧张力，随着吸入所测试的氧气和二氧化碳气体混合物而增加。与R/A相比，吸入100%氧气可增加中位pO₂，但吸入任何一种卡波金气体混合物时氧张力的增加更为显著。吸入纯氧并未降低≤2.5 mmHg值的百分比，而吸入2.5%和5%卡波金气体均导致该参数显著降低。用Eppendorf pO₂组织氧张力仪测量时，两种卡波金浓度在增加原发性妇科肿瘤的氧张力方面似乎效果相同。
