通过计算机化的p02组织学评估卡波金呼吸对人体肿瘤组织氧合的影响。
The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography.
作者信息
Falk S J, Ward R, Bleehen N M
机构信息
MRC Unit, Cambridge, UK.
出版信息
Br J Cancer. 1992 Nov;66(5):919-24. doi: 10.1038/bjc.1992.386.
Tumour tissue oxygenation has been measured in man during carbogen breathing (95% O2, 5% CO2) using a commercially available polarographic electrode system (Eppendorf p02 histograph). At least 200 tumour measurements in each of 17 patients with accessible tumours were taken before, and subsequently continuously after the commencement of carbogen breathing for periods of 10 to 30 min. In 12 out of 17 patients studied there was a significant increase in median tumour p02 during the first 10 min of carbogen breathing (range 9 to 1800%). There was an initial rapid increase in tumour p02 which was maintained until 8 to 12 min, but then decreased throughout the subsequent treatment period. Although there was a reduction in the proportion of point measurements < or = 10 mmHg in 11 out of 13 patients, during carbogen breathing, measured points of < or = 2.5 mmHg were only eliminated in three out of 11 tumours. The time course has implications for the planning of clinical trials utilising radiotherapy with carbogen breathing.
使用市售的极谱电极系统（Eppendorf p02组织氧测定仪）在人体中测量了肿瘤组织在吸入卡波金（95% O₂，5% CO₂）期间的氧合情况。对17名可触及肿瘤患者中的每一位，在吸入卡波金之前至少进行了200次肿瘤测量，随后在吸入卡波金开始后的10至30分钟内持续进行测量。在17名接受研究的患者中，有12名在吸入卡波金的前10分钟内肿瘤p0₂中位数显著增加（范围为9%至1800%）。肿瘤p0₂最初迅速增加，并持续到8至12分钟，但在随后的治疗期间整体下降。尽管在13名患者中有11名在吸入卡波金期间测量值≤10 mmHg的点的比例有所降低，但在11个肿瘤中只有3个消除了测量值≤2.5 mmHg的点。这种时间进程对利用卡波金呼吸辅助放疗的临床试验规划具有启示意义。
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