Karoui S, Boubaker J, Hamzaoui S, Ben Yaghlene L, Filali A
Service de Gastro-Entérologie A, Hôpital La Rabta, 1007 Tunis, Tunisie.
Ann Med Interne (Paris). 2000 Sep;151(5):411-2.
A 24-year-old woman had Crohn's colitis which had been diagnosed in 1997. The patient was given sulfazalazine and responded well. Antiendomysial and antigliadin antibodies were positive. Diagnosis of celiac disease was confirmed by duodenal biopsy showing villous atrophy and an increased number of lymphocytes infiltrating the epithelium. Few cases associating Crohn's disease and celiac disease have been reported. This case illustrates the complexity of the pathogenic mechanisms in these two disease. Our patient required a gluten-free diet although the celiac disease was asymptomatic, basically to avoid the risk of malignancy associated with celiac disease.
一名24岁女性于1997年被诊断为克罗恩结肠炎。患者接受柳氮磺胺吡啶治疗，反应良好。抗肌内膜抗体和抗麦醇溶蛋白抗体呈阳性。十二指肠活检显示绒毛萎缩且上皮内淋巴细胞浸润数量增加，从而确诊为乳糜泻。报道的克罗恩病与乳糜泻相关的病例很少。该病例说明了这两种疾病致病机制的复杂性。尽管患者的乳糜泻没有症状，但仍需无麸质饮食，主要是为了避免与乳糜泻相关的恶性肿瘤风险。
