Bertrand P, Faro A, Cantwell P, Tzakis A
Department of Pediatrics, University of Miami, Florida, USA.
Pharmacotherapy. 2000 Oct;20(10):1216-20. doi: 10.1592/phco.20.15.1216.34582.
Ribavirin is a synthetic guanosine analog with activity against DNA and RNA viruses. It was studied in human trials, and no marked adverse effect was reported beyond the potential for teratogenicity and reversible mild anemia. An 8-year-old girl received a multivisceral transplant and developed adenoviral pneumonia. She was treated with intravenous ribavirin and became hyperammonemic. Discontinuation of ribavirin led to a decrease in ammonia levels. This pattern was repeated when the drug was restarted and discontinued. We hypothesize that in a toxic environment the interaction of ribavirin with hepatocellular mitochondrial enzymes may lead to hyperammonemia.
利巴韦林是一种合成的鸟苷类似物，对DNA和RNA病毒均有活性。在人体试验中对其进行了研究，除了有致畸性和可逆性轻度贫血的可能性外，未报告有明显的不良反应。一名8岁女孩接受了多脏器移植，并发腺病毒性肺炎。她接受了静脉注射利巴韦林治疗，随后出现高氨血症。停用利巴韦林后氨水平下降。当再次使用和停用该药物时，这种情况再次出现。我们推测，在有毒环境中，利巴韦林与肝细胞线粒体酶的相互作用可能导致高氨血症。
