Linares J L, Wendling C, Tomasetto C, Rio M C
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM U184/ULP BP 163, Illkirch, CU de Strasbourg, France.
FEBS Lett. 2000 Sep 1;480(2-3):249-54. doi: 10.1016/s0014-5793(00)01942-6.
C2PA is a novel protein that contains a C2 membrane binding domain, a PDZ protein/protein interaction domain, and an ATP/GTP binding domain. C2PA is expressed during embryogenesis from 8.5 days post-coitum (dpc) until birth. After birth, C2PA expression is mainly observed in the post-natal and adult testis. During spermatogenesis, C2PA transcripts are specifically observed in the spermatocytes, whereas spermatogonia and spermatids are negative. Taken together, these results suggest that C2PA might be involved in cell signaling pathways occurring during spermatogenesis.
C2PA是一种新型蛋白质，它包含一个C2膜结合结构域、一个PDZ蛋白/蛋白相互作用结构域和一个ATP/GTP结合结构域。C2PA在胚胎发育过程中从交配后8.5天（dpc）开始表达直至出生。出生后，C2PA表达主要在出生后及成年睾丸中观察到。在精子发生过程中，C2PA转录本在精母细胞中特异性观察到，而精原细胞和精子细胞则为阴性。综上所述，这些结果表明C2PA可能参与精子发生过程中发生的细胞信号通路。
