Granadino B, Arias-de-la-Fuente C, Pérez-Sánchez C, Párraga M, López-Fernández L A, del Mazo J, Rey-Campos J
Centro de Investigaciones Biológicas, CSIC, Velazquez 144, 28006, Madrid, Spain.
Mech Dev. 2000 Oct;97(1-2):157-60. doi: 10.1016/s0925-4773(00)00410-x.
FHX (FOXJ2) is a recently characterized human fork head transcriptional activator that binds DNA with a dual sequence specificity. We have cloned the cDNA for the mouse orthologue Foxj2 and characterized its expression in the gonads and along the early pre-implantation development of the mouse. In the testis, Foxj2 is expressed from pachytene spermatocytes to round spermatids, but not in spermatogonia. In addition to the germ lineage, only Sertoli cells of the testis showed expression of Foxj2. In the ovary, only granulosa cells of the follicles express the factor. Neither mature spermatozoa nor oocytes showed expression of Foxj2. Foxj2 expression is early activated in zygotic development, being detected since as early as 8-cell stage embryos. Both cell layers of the blastocyst: the trophectoderm (TE) and the inner cell mass (ICM), express Foxj2.
FHX（FOXJ2）是一种最近被鉴定出来的人类叉头转录激活因子，它以双重序列特异性结合DNA。我们已经克隆了小鼠同源物Foxj2的cDNA，并对其在性腺以及小鼠植入前早期发育过程中的表达进行了表征。在睾丸中，Foxj2从粗线期精母细胞到圆形精子细胞都有表达，但在精原细胞中不表达。除生殖谱系外，睾丸中仅支持细胞显示出Foxj2的表达。在卵巢中，仅卵泡的颗粒细胞表达该因子。成熟精子和卵母细胞均未显示出Foxj2的表达。Foxj2在合子发育早期被激活，早在8细胞期胚胎就可检测到。囊胚的两个细胞层：滋养外胚层（TE）和内细胞团（ICM）都表达Foxj2。
