Scheja A, Wildt M, Wollheim F A, Akesson A, Saxne T
Department of Rheumatology, University Hospital, Lund, Sweden.
Rheumatology (Oxford). 2000 Oct;39(10):1110-3. doi: 10.1093/rheumatology/39.10.1110.
To study collagen metabolites in systemic sclerosis (SSc) and their relationship with clinical manifestations of the disease.
Forty-eight SSc patients, 13 with a diffuse form (dcSSc), 23 with a limited form (lcSSc) and 12 with suspected SSc not fulfilling the ACR criteria, and 31 healthy controls were examined. Serum concentrations of aminoterminal type III procollagen peptide (PIIINP), aminoterminal and carboxyterminal type I procollagen peptides (PINP and PICP) and cross-linked carboxyterminal telopeptide of collagen I (ICTP) were determined by radioimmunoassay.
Increased serum concentrations of ICTP were found in SSc patients compared with controls. Distinctly higher levels of ICTP were observed in dcSSc than in lcSSc. High serum ICTP was correlated with skin score and acute phase reactants, and with reduced pulmonary function. Serum PIIINP concentration was elevated in both lcSSc and dcSSc.
Augmented collagen catabolism accompanies the increased collagen synthesis in SSc. Serum ICTP concentration is a marker of this feature and also reflects clinical severity.
研究系统性硬化症（SSc）中的胶原代谢产物及其与该疾病临床表现的关系。
对48例SSc患者进行检查，其中13例为弥漫型（dcSSc），23例为局限型（lcSSc），12例疑似SSc但不符合美国风湿病学会（ACR）标准，另选取31名健康对照者。采用放射免疫分析法测定血清中Ⅲ型前胶原氨基端肽（PIIINP）、Ⅰ型前胶原氨基端和羧基端肽（PINP和PICP）以及Ⅰ型胶原交联羧基末端肽（ICTP）的浓度。
与对照组相比，SSc患者血清ICTP浓度升高。dcSSc患者的ICTP水平明显高于lcSSc患者。血清ICTP水平升高与皮肤评分、急性期反应物以及肺功能下降相关。lcSSc和dcSSc患者的血清PIIINP浓度均升高。
在SSc中，胶原分解代谢增强伴随着胶原合成增加。血清ICTP浓度是这一特征的标志物，也反映了临床严重程度。
