Hettema M E, Bootsma H, Graaff R, de Vries R, Kallenberg C G M, Smit A J
Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Int J Rheumatol. 2011;2011:417813. doi: 10.1155/2011/417813. Epub 2011 Sep 29.
Objective. To investigate whether advanced glycation endproducts (AGEs) in the skin are increased in patients with systemic sclerosis (SSc) and are related to the presence of disease-related and traditional cardiovascular risk factors. Methods. Skin autofluorescence, as a measure for the accumulation of AGEs, was assessed by measuring UV-A light excitation-emission matrices (AF-EEMS) in 41 SSc patients and 41 age- and sex-matched controls. Traditional cardiovascular risk factors and disease-related risk factors were recorded. Results. Skin AF-EEMS did not differ between SSc patients and controls (1.68 ± 0.58 a.u. versus 1.63 ± 0.41 a.u., P = 0.684). Skin AF-EEMS in SSc patients was associated with levels of CRP (r = 0.44, P = 0.004), Medsger's severity scale (r = 0.45, P = 0.006), and use of agents intervening in the renin-angiotensin system (r = 0.33, P = 0.027). When analysing SSc patients and controls together, in multivariate analysis, only age and use of agents intervening in the renin-angiotensin system were independently associated with AF-EEMS. Conclusion. These data demonstrate that skin AGEs are not increased in SSc patients.
目的。研究系统性硬化症（SSc）患者皮肤中晚期糖基化终产物（AGEs）是否增加，以及是否与疾病相关和传统心血管危险因素的存在有关。方法。通过测量41例SSc患者和41例年龄及性别匹配的对照者的紫外线-A光激发-发射矩阵（AF-EEMS），评估皮肤自发荧光作为AGEs积累的一种测量方法。记录传统心血管危险因素和疾病相关危险因素。结果。SSc患者和对照者的皮肤AF-EEMS无差异（1.68±0.58任意单位对1.63±0.41任意单位，P = 0.684）。SSc患者的皮肤AF-EEMS与CRP水平（r = 0.44，P = 0.004）、Medsger严重程度量表（r = 0.45，P = 0.006）以及使用干预肾素-血管紧张素系统的药物（r = 0.33，P = 0.027）相关。当将SSc患者和对照者一起分析时，在多变量分析中，只有年龄和使用干预肾素-血管紧张素系统的药物与AF-EEMS独立相关。结论。这些数据表明SSc患者皮肤中的AGEs没有增加。
