阿片肽对人体过度通气循环反应的调节作用。

Opioid peptide modulation of circulatory response to hyperventilation in humans.

作者信息

Fontana F, Bernardi P, Pich E M, Tartuferi L, Boschi S, Spampinato S

机构信息

Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Ospedale S. Orsola, Via Massarenti 9, 40138 Bologna, Italy.

出版信息

Peptides. 2000 Aug;21(8):1223-30. doi: 10.1016/s0196-9781(00)00263-1.

DOI:10.1016/s0196-9781(00)00263-1

PMID:11035209

Abstract

After hyperventilation, systolic blood pressure (SBP) significantly decreased in 10 subjects (group 1), did not change in eight (group 2) and increased in 15 (group 3). Diastolic blood pressure and heart rate increased in all groups. The decrease in SBP was associated with a decrease in plasma catecholamines and increase in beta-endorphin, whereas the increase in SBP was accompanied by an increase in catecholamine and Met-enkephalin levels. Naloxone abolished the hyperventilation-induced SBP and catecholamine decrease only in group 1. These findings show an activation of the endogenous opioid system after hyperventilation and the role of beta-endorphin in reducing SBP in response to the test.

摘要

过度通气后，10名受试者（第1组）的收缩压（SBP）显著降低，8名受试者（第2组）的收缩压未发生变化，15名受试者（第3组）的收缩压升高。所有组的舒张压和心率均升高。收缩压降低与血浆儿茶酚胺减少及β-内啡肽增加有关，而收缩压升高则伴随着儿茶酚胺和甲硫氨酸脑啡肽水平的增加。纳洛酮仅在第1组中消除了过度通气引起的收缩压和儿茶酚胺降低。这些发现表明过度通气后内源性阿片系统被激活，以及β-内啡肽在应对该测试时降低收缩压的作用。