Sevanian A, Ursini F
University of Southern California, Department of Molecular Pharmacology & Toxicology, School of Pharmacy, Los Angeles 90089, USA.
Free Radic Biol Med. 2000 Aug;29(3-4):306-11. doi: 10.1016/s0891-5849(00)00342-7.
Lipid peroxidation has been a central aspect of studies of the nature of free radical species and their origin in biological systems. Moreover, there has been a growing interest in lipid peroxidation based on evidence that biologically active products are formed that influence cell function and the course of major human diseases. A review of the work in this area is contributed by Lars Ernster is presented with an emphasis on the mechanisms by which lipid peroxidation is initiated in biological lipid systems. Based on what was described for metal catalyzed oxidation of cell membranes, and the seminal studies on cytochrome P-450-mediated lipid peroxidation, several parallel and distinct aspects of lipid peroxidation are described. A key distinction between lipid peroxidation in cell membranes and lipoproteins reveals aspects of free radical initiated reactions involving proteins and lipids that determine pro- vs. anti-oxidant outcomes, and the role of lipid structure and order in delineating the progress of oxidation.
脂质过氧化一直是自由基种类的性质及其在生物系统中起源研究的核心内容。此外，基于有证据表明形成了影响细胞功能和主要人类疾病进程的生物活性产物，人们对脂质过氧化的兴趣与日俱增。拉尔斯·厄恩斯特对该领域的工作进行了综述，重点介绍了生物脂质系统中引发脂质过氧化的机制。基于对细胞膜金属催化氧化的描述以及对细胞色素P - 450介导的脂质过氧化的开创性研究，阐述了脂质过氧化的几个平行且不同的方面。细胞膜和脂蛋白中脂质过氧化的一个关键区别揭示了涉及蛋白质和脂质的自由基引发反应的各个方面，这些反应决定了抗氧化与促氧化的结果，以及脂质结构和有序性在描绘氧化进程中的作用。
