Suriawinata A, Ye M Q, Emre S, Strauchen J, Thung S N
Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Arch Pathol Lab Med. 2000 Oct;124(10):1532-4. doi: 10.5858/2000-124-1532-HCANHL.
Hepatitis C virus (HCV) is a hepatotropic virus, but its genome and replicative intermediates also have been detected in peripheral blood mononuclear cells in patients with chronic hepatitis C. Chronic HCV infection may lead to hepatocellular carcinoma and, in a small percentage of cases, to B-cell non-Hodgkin lymphoma. To our knowledge, coexistence of these 2 tumors has not been reported previously. We describe a case of chronic hepatitis C and cirrhosis with 2 small hepatocellular carcinomas and incidental non-Hodgkin lymphoma of a hilar lymph node found during liver transplantation. Although the mechanisms of HCV oncogenesis in hepatocellular carcinoma and in lymphoma are unclear, the presence of these 2 tumors in a single patient are in agreement with the tropism of HCV and its role in oncogenesis.
丙型肝炎病毒（HCV）是一种嗜肝病毒，但在慢性丙型肝炎患者的外周血单核细胞中也检测到了其基因组和复制中间体。慢性HCV感染可能导致肝细胞癌，在少数情况下还会导致B细胞非霍奇金淋巴瘤。据我们所知，此前尚未报道过这两种肿瘤并存的情况。我们描述了一例慢性丙型肝炎和肝硬化患者，在肝移植过程中发现了2个小肝细胞癌以及肝门淋巴结偶然出现的非霍奇金淋巴瘤。虽然HCV在肝细胞癌和淋巴瘤中致癌的机制尚不清楚，但这两种肿瘤在同一患者体内的出现与HCV的嗜性及其在致癌过程中的作用是一致的。
