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1
Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998.1993年至1998年日本淋病奈瑟菌的抗菌药物耐药性及耐环丙沙星分离株的高流行率。
J Clin Microbiol. 2000 Feb;38(2):521-5. doi: 10.1128/JCM.38.2.521-525.2000.
2
Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations.由于mtrR基因突变导致淋病奈瑟菌对阿奇霉素敏感性降低。
Antimicrob Agents Chemother. 1999 Oct;43(10):2468-72. doi: 10.1128/AAC.43.10.2468.
3
Alterations within the quinolone resistance-determining regions of GyrA and ParC of Neisseria gonorrhoeae isolated in the Far East and the United States.在远东地区和美国分离出的淋病奈瑟菌的GyrA和ParC喹诺酮耐药决定区的改变。
Int J Antimicrob Agents. 1999 Aug;12(4):325-32. doi: 10.1016/s0924-8579(99)00081-3.
4
Development of fluoroquinolone resistance and mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae isolates in Japan.日本淋病奈瑟菌分离株中氟喹诺酮耐药性的发展以及涉及GyrA和ParC蛋白的突变
J Urol. 1998 Jun;159(6):2215-9. doi: 10.1016/S0022-5347(01)63308-1.
5
Surveillance of antibiotic resistance in Neisseria gonorrhoeae in The Netherlands, 1977-95.1977 - 1995年荷兰淋病奈瑟菌抗生素耐药性监测
Genitourin Med. 1997 Dec;73(6):510-7. doi: 10.1136/sti.73.6.510.
6
Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.淋病奈瑟菌在耐氟喹诺酮类药物的分离株中，gyrA和parC的类似区域会发生突变。
Mol Microbiol. 1994 Oct;14(2):371-80. doi: 10.1111/j.1365-2958.1994.tb01297.x.
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[The influence of HIV infections on the demand for assistance in an outpatient clinic for venereal diseases].[艾滋病病毒感染对性病门诊援助需求的影响]
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1991年至1998年荷兰淋病奈瑟菌的抗菌药物耐药性及环丙沙星耐药性的出现

Antimicrobial resistance of Neisseria gonorrhoeae and emerging ciprofloxacin resistance in the Netherlands, 1991 to 1998.

作者信息

de Neeling A J, van Santen-Verheuvel M, Spaargaren J, Willems R J

机构信息

Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands.

出版信息

Antimicrob Agents Chemother. 2000 Nov;44(11):3184-5. doi: 10.1128/AAC.44.11.3184-3185.2000.

DOI:10.1128/AAC.44.11.3184-3185.2000
PMID:11036048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC101628/
Abstract

Surveillance of antibiotic resistance in Neisseria gonorrhoeae showed a decrease in the percentage of beta-lactamase-producing isolates but an increase in intermediately penicillin-resistant strains and strains resistant to a high level of tetracycline. MICs for the ciprofloxacin-resistant isolates that emerged increased, and these isolates had mutations in gyrA and parC similar to those observed in the Far East.

摘要

淋病奈瑟菌抗生素耐药性监测显示，产β-内酰胺酶菌株的百分比有所下降，但对青霉素中度耐药菌株和对高剂量四环素耐药菌株的比例有所上升。新出现的耐环丙沙星菌株的最低抑菌浓度（MIC）增加，且这些菌株在gyrA和parC基因上发生的突变与在远东地区观察到的类似。