1991年至1998年荷兰淋病奈瑟菌的抗菌药物耐药性及环丙沙星耐药性的出现
Antimicrobial resistance of Neisseria gonorrhoeae and emerging ciprofloxacin resistance in the Netherlands, 1991 to 1998.
作者信息
de Neeling A J, van Santen-Verheuvel M, Spaargaren J, Willems R J
机构信息
Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3184-5. doi: 10.1128/AAC.44.11.3184-3185.2000.
Abstract
Surveillance of antibiotic resistance in Neisseria gonorrhoeae showed a decrease in the percentage of beta-lactamase-producing isolates but an increase in intermediately penicillin-resistant strains and strains resistant to a high level of tetracycline. MICs for the ciprofloxacin-resistant isolates that emerged increased, and these isolates had mutations in gyrA and parC similar to those observed in the Far East.
摘要
淋病奈瑟菌抗生素耐药性监测显示，产β-内酰胺酶菌株的百分比有所下降，但对青霉素中度耐药菌株和对高剂量四环素耐药菌株的比例有所上升。新出现的耐环丙沙星菌株的最低抑菌浓度（MIC）增加，且这些菌株在gyrA和parC基因上发生的突变与在远东地区观察到的类似。
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