Sato S, Miyauchi M, Takekoshi T, Zhao M, Kudo Y, Ogawa I, Kitagawa S, Fujita M, Takata T
Department of Oral Pathology, Faculty of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Japan.
Oral Oncol. 2000 Nov;36(6):545-9. doi: 10.1016/s1368-8375(00)00049-x.
Expression of CD44v9 was immunohistochemically studied in 120 biopsy specimens from primary squamous cell carcinoma (SCC) of the tongue and correlated with clinicopathological findings of the SCCs. The tumors were classified into three groups according to immunostaining pattern of CD44v9; 53 cases with distinct positivity in all cancer cells except for those in the central part of nests (Group 1, non-reduced group), 42 cases with reduced expression in peripheral cells of nests (Group 2, reduced group), and 25 cases with complete disappearance of the expression in one or more nests (Group 3, negative group). Nineteen of 25 (76%) tumors in Group 3 and 14 of 42 (33%) in Group 2 exhibited lymph node metastasis, compared with only 8 of 53 (15%) in Group 1. The average survival time in Groups 1, 2 and 3 was 4496+/-204, 3866+/-379 and 2719+/-359 days, respectively and became shorter with the reduction of CD44v9 expression. These results suggest that the down-regulation of CD44v9 in SCC of the tongue may relate to the detachment of tumor cells from primary lesions, establishment of lymph node metastasis and consequently the death of patients.
采用免疫组织化学方法研究了120例舌原发性鳞状细胞癌活检标本中CD44v9的表达情况，并将其与鳞状细胞癌的临床病理结果进行关联分析。根据CD44v9的免疫染色模式，将肿瘤分为三组：53例除巢中央细胞外所有癌细胞均呈明显阳性（第1组，非降低组）；42例巢周边细胞表达降低（第2组，降低组）；25例一个或多个巢中表达完全消失（第3组，阴性组）。第3组25例肿瘤中有19例（76%）、第2组42例中有14例（33%）出现淋巴结转移，而第1组53例中只有8例（15%）出现淋巴结转移。第1、2和3组的平均生存时间分别为4496±204天、3866±379天和2719±359天，且随着CD44v9表达的降低而缩短。这些结果表明，舌鳞状细胞癌中CD44v9的下调可能与肿瘤细胞从原发灶脱离、发生淋巴结转移以及患者死亡有关。
