Kunishi M, Kayada Y, Yoshiga K
Department of Oral and Maxillofacial Surgery 1, Hiroshima University School of Dentistry, Japan.
Int J Oral Maxillofac Surg. 1997 Aug;26(4):280-3. doi: 10.1016/s0901-5027(97)80869-7.
The expression of the adhesion molecule CD44 variant 6 (CD44v6) was studied immunohistochemically on 38 oral squamous cell carcinomas (SCCs) and 10 biopsies of healthy oral mucosa. The relationship between the expression of CD44v6 and regional lymph node metastasis was also investigated. The expression of CD44v6 was apparently down-regulated in oral SCC, but not in normal oral mucosa. Carcinomas expressing lower levels of CD44v6 exhibited more frequent regional lymph node metastasis. The expression of CD44v6 showed no statistically significant relationship to the degree of differentiation, but tended to be down-regulated in poorly differentiated carcinoma. No significant relation was found between the expression of CD44v6 in primary and metastatic lesions.
采用免疫组织化学方法，对38例口腔鳞状细胞癌（SCC）及10例健康口腔黏膜活检标本进行了黏附分子CD44变异体6（CD44v6）表达情况的研究。同时，还对CD44v6表达与区域淋巴结转移之间的关系进行了调查。CD44v6在口腔SCC中表达明显下调，但在正常口腔黏膜中无此现象。CD44v6表达水平较低的癌组织区域淋巴结转移更为频繁。CD44v6的表达与分化程度无统计学显著关系，但在低分化癌中倾向于下调。在原发性和转移性病变中，未发现CD44v6表达之间存在显著关系。
