Eldridge L L, Knowlton B J, Furmanski C S, Bookheimer S Y, Engel S A
Department of Psychology, University of California, Los Angeles, Box 951563, Franz Hall, Los Angeles, California 90095-1563, USA.
Nat Neurosci. 2000 Nov;3(11):1149-52. doi: 10.1038/80671.
Some memories are linked to a specific time and place, allowing one to re-experience the original event, whereas others are accompanied only by a feeling of familiarity. To uncover the distinct neural bases for these two types of memory, we measured brain activity during memory retrieval using event-related functional magnetic resonance imaging. We show that activity in the hippocampus increased only when retrieval was accompanied by conscious recollection of the learning episode. Hippocampal activity did not increase for items recognized based on familiarity or for unrecognized items. These results indicate that the hippocampus selectively supports the retrieval of episodic memories.
有些记忆与特定的时间和地点相关联，使人能够重新体验最初的事件，而另一些记忆仅伴随着一种熟悉感。为了揭示这两种记忆类型不同的神经基础，我们在记忆提取过程中使用事件相关功能磁共振成像测量大脑活动。我们发现，只有当提取伴随着对学习事件的有意识回忆时，海马体的活动才会增加。基于熟悉度识别的项目或未被识别的项目，海马体活动并未增加。这些结果表明，海马体选择性地支持情景记忆的提取。
