Laboratory of Neurophysiology of Memory, Institute of Physiology, Czech Academy of Sciences, Prague 142 20, Czechia
Department of Physiology, Second Faculty of Medicine, Charles University, Prague 150 06, Czechia.
eNeuro. 2024 Aug 30;11(8). doi: 10.1523/ENEURO.0073-24.2024. Print 2024 Aug.
Episodic memory, the ability to recall specific events and experiences, is a cornerstone of human cognition with profound clinical implications. While animal studies have provided valuable insights into the neuronal underpinnings of episodic memory, research has largely relied on a limited subset of tasks that model only some aspects of episodic memory. In this narrative review, we provide an overview of rodent episodic-like memory tasks that expand the methodological repertoire and diversify the approaches used in episodic-like memory research. These tasks assess various aspects of human episodic memory, such as integrated or , source memory, free recall, temporal binding, and threshold retrieval dynamics. We review each task's general principle and consider whether alternative non-episodic mechanisms can account for the observed behavior. While our list of tasks is not exhaustive, we hope it will guide researchers in selecting models that align with their specific research objectives, leading to novel advancements and a more comprehensive understanding of mechanisms underlying specific aspects of episodic memory.
情景记忆,即回忆特定事件和经历的能力,是人类认知的基石,具有深远的临床意义。虽然动物研究为情景记忆的神经基础提供了有价值的见解,但研究主要依赖于有限的任务集,这些任务仅模拟了情景记忆的某些方面。在这篇叙述性综述中,我们概述了啮齿类动物类情景记忆任务,这些任务扩展了方法学的范围,并使类情景记忆研究中使用的方法多样化。这些任务评估了人类情景记忆的各个方面,例如整合记忆或源记忆、自由回忆、时间绑定和阈检索动态。我们回顾了每个任务的一般原则,并考虑了替代的非情景记忆机制是否可以解释观察到的行为。虽然我们列出的任务不是详尽无遗的,但我们希望它能指导研究人员选择与特定研究目标相匹配的模型,从而推动新的进展,并更全面地了解情景记忆特定方面的机制。