嘧啶二聚体在紫外线照射的大肠杆菌K12切除缺陷细胞复制后修复过程中的分布

Distribution of pyrimidine dimers during postreplication repair in UV-irradiated excision-deficient cells of Escherichia coli K12.

作者信息

Ganesan A

出版信息

Basic Life Sci. 1975;5A:317-20. doi: 10.1007/978-1-4684-2895-7_42.

Abstract

During postreplication repair in excision-deficient mutants of Escherichia coli K-12, pyrimidine dimers are gradually lost from UV-irradiated DNA. Our data indicate that dimers are transferred, by a process which may involve genetic exchange, into daughter strands made after irradiation. Dimer transfer appears to continue through several rounds of replication, resulting in the gradual dilution of dimers into successive generations of DNA molecules.

摘要

在大肠杆菌K-12切除缺陷型突变体的复制后修复过程中，嘧啶二聚体逐渐从紫外线照射的DNA中丢失。我们的数据表明，二聚体通过一个可能涉及基因交换的过程转移到照射后合成的子代链中。二聚体转移似乎会持续经过几轮复制，导致二聚体逐渐稀释到连续几代的DNA分子中。