Hewitt R R, Meyn R E
Basic Life Sci. 1975;5B:635-8. doi: 10.1007/978-1-4684-2898-8_35.
Irradiated UV-sensitive bacteria which are mutant in the uvrA6 locus, and cannot excise pyrimidine dimers, are capable of continued DNA replication with the same orientation as that in unirradiated cells. Replication of dimer-containing DNA is also accomplished by irradiated mammalian cells, suggesting that pyrimidine dimers do not act as absolute blocks to DNA synthesis. Thus, the role that dimers play in reducing the amount and size of DNA synthesized after exposure must be reassessed.
在uvrA6位点发生突变且无法切除嘧啶二聚体的经紫外线照射的紫外线敏感细菌，能够以与未照射细胞相同的方向继续进行DNA复制。含二聚体的DNA的复制也可由经照射的哺乳动物细胞完成，这表明嘧啶二聚体并非DNA合成的绝对障碍。因此，必须重新评估二聚体在减少暴露后合成的DNA数量和大小方面所起的作用。
