El-Shorbagi A N
Faculty of Pharmacy, University of Assiut, Egypt.
Arch Pharm (Weinheim). 2000 Sep;333(9):281-6. doi: 10.1002/1521-4184(20009)333:9<281::aid-ardp281>3.0.co;2-e.
The deacylated chloramphenicol amine D-(-)-threo-2-amino-1-(4-nitrophenyl)-1,3-diol (D-amine, 1a), and its enantiomer, the L-(+)-threo-form (L-amine, 1b), were introduced into a tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) skeleton. They are incorporated in three ways (Chart 1, types I-III) at N3 (type I), N5 (type II) or both N3 and N5 (type III) of the THTT system. These selections were made in order to investigate the effect of combining the structural features of the THTT and the D-amine on the antimicrobial activity, if any.
将脱酰基氯霉素胺D-(-)-苏式-2-氨基-1-(4-硝基苯基)-1,3-二醇（D-胺，1a）及其对映体L-(+)-苏式异构体（L-胺，1b）引入四氢-2H-1,3,5-噻二嗪-2-硫酮（THTT）骨架中。它们通过三种方式（图1，I-III型）并入THTT体系的N3（I型）、N5（II型）或N3和N5两者（III型）。进行这些选择是为了研究将THTT和D-胺的结构特征结合起来对抗菌活性（如果有的话）的影响。
