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噻二嗪类，具有生物相关性的 N,N-杂环。

Thiadiazines, N,N-heterocycles of biological relevance.

机构信息

Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, Barcelona 08028, Spain.

出版信息

Molecules. 2012 Jun 25;17(7):7612-28. doi: 10.3390/molecules17077612.

DOI:10.3390/molecules17077612
PMID:22732878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268759/
Abstract

The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-substituents influences the overall activity and cytotoxicity profile will also be discussed.

摘要

3,5-二取代四氢-2H-1,3,5-噻二嗪-2-硫酮骨架近年来在许多领域得到了广泛应用。本文旨在重点介绍这些化合物的重要方面：合成、光谱特性和生物活性。还将讨论 N-取代基的化学性质如何影响整体活性和细胞毒性特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500c/6268759/db702db410d1/molecules-17-07612-g016.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500c/6268759/4d08b19c9c14/molecules-17-07612-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500c/6268759/88d5358d7c1f/molecules-17-07612-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500c/6268759/089944036f07/molecules-17-07612-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500c/6268759/61f1dfcb63c0/molecules-17-07612-g019.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500c/6268759/99c7a321b266/molecules-17-07612-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500c/6268759/112853eb47d9/molecules-17-07612-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/500c/6268759/7ebe5ea30693/molecules-17-07612-g012.jpg
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