噻二嗪类，具有生物相关性的 N,N-杂环。
Thiadiazines, N,N-heterocycles of biological relevance.
机构信息
Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, Barcelona 08028, Spain.
出版信息
Molecules. 2012 Jun 25;17(7):7612-28. doi: 10.3390/molecules17077612.
Abstract
The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-substituents influences the overall activity and cytotoxicity profile will also be discussed.
摘要
3,5-二取代四氢-2H-1,3,5-噻二嗪-2-硫酮骨架近年来在许多领域得到了广泛应用。本文旨在重点介绍这些化合物的重要方面：合成、光谱特性和生物活性。还将讨论 N-取代基的化学性质如何影响整体活性和细胞毒性特征。
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