Podrouzek P, Mardesić T
Sanatorium Pronatal, Praha.
Ceska Gynekol. 2000 Jul;65(4):260-8.
To review the recent progress in the diagnosis, pathophysiology and treatment of polycystic ovary disease (PCOD).
A review describing the progress in understanding of the dysregulation of ovarian androgen biosynthesis in polycystic ovary disease (PCOD).
The Institute for the Care of Mother and Child, Podolské nábr. 157, 147 10 Prague 4, Sanatorium Pronatal, Na Dlouhé mezi 4/12, 147 00 Praha 4-Hodkovicky.
It is proposed, that although this syndrome is very heterogeneous, the final common pathway involves a dysregulation of enzymes responsible for ovarian androgen biosynthesis, possibly induced/influenced by extraovarian factors--especially insulin resistance, hyperinsulinaemie, growth factors, luteinizing hormone and their biochemical sequelae. It's probably extraovarian factors that determine endocrinological and clinical expression of the disease.
综述多囊卵巢疾病（PCOD）在诊断、病理生理学及治疗方面的最新进展。
一篇描述多囊卵巢疾病（PCOD）中卵巢雄激素生物合成失调相关认识进展的综述。
母婴护理研究所，Podolské nábr. 157，147 10布拉格4区；产前疗养院，Na Dlouhé mezi 4/12，147 00布拉格4-霍德科维采区。
尽管该综合征具有高度异质性，但最终共同通路涉及负责卵巢雄激素生物合成的酶失调，这可能由卵巢外因素诱导/影响，尤其是胰岛素抵抗、高胰岛素血症、生长因子、促黄体生成素及其生化后遗症。可能是卵巢外因素决定了该疾病的内分泌及临床表型。
