Schriock E, Martin M C, Jaffe R B
West J Med. 1985 Apr;142(4):519-22.
Polycystic ovarian disease represents a poorly defined spectrum of clinical disorders having oligo-ovulation or anovulation as a common feature. There is no single, universally accepted biochemical or clinical definition. Clinical findings usually include anovulation resulting in irregular uterine bleeding and infertility, androgen excess resulting in hirsutism and acne, and obesity. The patho-physiology involves altered functions of the hypothalamus, pituitary, ovary and adrenal glands, resulting in failure of folliculogenesis to regularly proceed to ovulation. The cause of the initiating event in this disease process remains enigmatic. Therapy for the various abnormalities in polycystic ovarian disease is tailored to a patient's needs and may include preventing endometrial hyperplasia, controlling irregular uterine bleeding, controlling hirsutism and inducing ovulation.
多囊卵巢疾病代表了一系列定义不明确的临床病症，其共同特征是排卵少或无排卵。目前尚无单一的、被普遍接受的生化或临床定义。临床症状通常包括因无排卵导致的子宫不规则出血和不孕、因雄激素过多导致的多毛症和痤疮以及肥胖。病理生理学涉及下丘脑、垂体、卵巢和肾上腺功能改变，导致卵泡生成无法正常进行至排卵。该疾病过程起始事件的原因仍不明朗。多囊卵巢疾病各种异常情况的治疗是根据患者的需求定制的，可能包括预防子宫内膜增生、控制子宫不规则出血、控制多毛症以及诱导排卵。
