Warin A P, Landells J W, Levene G M, Baker H
Br J Dermatol. 1975 Sep;93(3):321-7. doi: 10.1111/j.1365-2133.1975.tb06498.x.
The results are reported of a prospective study of liver histological findings in twenty-five patients with severe psoriasis subjected to liver biopsy before and at intervals after the onset of treatment with methotrexate by an intermittent dosage schedule. The pre-methotrexate liver biopsy findings in forty-one other severe psoriatics are also summarized. Of the twenty-five treated patients, four showed a mild inflammatory cell infiltrate and two mild fibrosis before treatment. During treatment only one developed a grade 2 infiltrate and one other grade 2 fibrosis. None has developed cirrhosis. Where minor abnormalities developed, their fluctuating and reversible nature is demonstrated.
报告了一项前瞻性研究的结果，该研究针对25例重度银屑病患者，在采用间歇给药方案进行甲氨蝶呤治疗之前及治疗开始后的不同时间间隔进行了肝脏活检，以观察肝脏组织学变化。同时也总结了另外41例重度银屑病患者在使用甲氨蝶呤治疗前的肝脏活检结果。在接受治疗的25例患者中，4例在治疗前显示轻度炎性细胞浸润，2例有轻度纤维化。治疗期间，仅1例出现2级浸润，另1例出现2级纤维化。无人发展为肝硬化。对于出现的轻微异常，研究证实了其波动及可逆的特性。
