Naganobu K, Ogawa H, Uchida K, Yamaguchi R, Ohashi F, Kubo K, Aoki M, Kuwamura M, Ogawa Y, Matsuyama K
Department of Veterinary Science, Faculty of Agriculture, Miyazaki University, Japan.
J Vet Med Sci. 2000 Sep;62(9):1009-11. doi: 10.1292/jvms.62.1009.
An 11-year-old male Shetland sheepdog displayed epistaxis and nasal discharge from the left nasal foramen. Cytological examination of a smear sample obtained by rhinotomy revealed neoplastic mast cells in the nasal cavity, a definitive diagnostic sign of mast cell tumor. The case was treated by surgery combined with radiotherapy and chemotherapy. Eighteen days after the last treatment, marked enlargement of the mandibular lymph nodes and facial edema developed, and the dog was euthanized at the owner's request. At necropsy, metastatic proliferation of mast cells was confirmed in the lymph nodes and liver, but no neoplastic mast cells were observed in the nasal cavity.
一只11岁的雄性设得兰牧羊犬出现鼻出血和左侧鼻孔流涕症状。通过鼻切开术获取的涂片样本进行细胞学检查，发现鼻腔中有肿瘤性肥大细胞，这是肥大细胞瘤的明确诊断迹象。该病例采用手术结合放疗和化疗进行治疗。最后一次治疗18天后，下颌淋巴结明显肿大并出现面部水肿，应主人要求对该犬实施了安乐死。尸检时，在淋巴结和肝脏中证实有肥大细胞的转移性增殖，但在鼻腔中未观察到肿瘤性肥大细胞。
