真菌性角膜炎药物治疗失败后的治疗性手术

Forster R K, Rebell G

Br J Ophthalmol. 1975 Jul;59(7):366-71. doi: 10.1136/bjo.59.7.366.

Medical treatment failure necessitated surgery in nine cases of fungal keratitis. Therapeutic surgery eliminated fungal infection in seven cases, and useful vision was retained in five out of six penetrating keratoplasties. In three cases Natamycin (Pimaricin) therapy rendered fungi non-viable, but two were demonstrable by histopathology. These results suggest that antifungal treatment should be applied for as long as possible before therapeutic surgery in order to improve the final visual outcome.

9例真菌性角膜炎因药物治疗失败而需要进行手术。治疗性手术清除了7例患者的真菌感染，6例穿透性角膜移植术中，有5例保留了有用视力。3例患者使用那他霉素（匹马霉素）治疗后真菌失去活性，但经组织病理学检查仍有2例可检测到真菌。这些结果表明，在进行治疗性手术前应尽可能长时间地应用抗真菌治疗，以改善最终的视觉效果。