Archibeck M J, Jacobs J J, Black J
Department of Orthopaedic Surgery, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA.
Clin Orthop Relat Res. 2000 Oct(379):12-21. doi: 10.1097/00003086-200010000-00003.
The problem of periprosthetic osteolysis is currently the major limiting factor in joint arthroplasty longevity. Because this process has been shown to be primarily a biologic response to wear particles, corrosion products, or both, efforts to reduce particle generation are being undertaken. These efforts include the development of modified polyethylene and alternative articulating surfaces. These alternate bearing surfaces currently include ceramic-on-polyethylene, ceramic-on-ceramic, and metal-on-metal. Although these alternate bearings diminish or eliminate the generation of polyethylene particles, ceramic and metal particles are produced. The purpose of the current review is to discuss the literature that addresses the biologic response to these particles, locally and systemically.
假体周围骨溶解问题目前是关节置换术长期效果的主要限制因素。由于这一过程已被证明主要是对磨损颗粒、腐蚀产物或两者的生物学反应，因此人们正在努力减少颗粒的产生。这些努力包括开发改性聚乙烯和替代关节表面。这些替代承重表面目前包括陶瓷对聚乙烯、陶瓷对陶瓷和金属对金属。尽管这些替代轴承减少或消除了聚乙烯颗粒的产生，但会产生陶瓷和金属颗粒。本综述的目的是讨论关于这些颗粒在局部和全身的生物学反应的文献。
