Shtrasburg S, Pras M, Dolitzky M, Pariente C, Gal R, Livneh A
Heller Institute of Medical Research, and the Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
J Lab Clin Med. 2000 Oct;136(4):314-9. doi: 10.1067/mlc.2000.109099.
The observation of a deleterious effect of pregnancy on kidney function in amyloidosis of familial Mediterranean fever suggests that pregnancy may enhance amyloidogenesis. To determine whether pregnancy may indeed affect amyloidogenesis, pregnant mice were made amyloidotic by administration of amyloid-enhancing factor (AEF) and AgNO3 at different points in time from conception, and amyloid- deposition was studied with the crush-and-smear technique. A possible effect of exogenous female sex hormones (beta-estradiol and progesterone) on amyloidogenesis was studied by administration of these hormones during amyloid induction in nonpregnant female mice. Amyloidogenesis was found to be significantly suppressed in mice during pregnancy. The reduction was possibly related to the effect of pregnancy on the inflammatory stimulus (AgNO3) and not on the administered AEF. Exogenous estrogen and progesterone failed to inhibit amyloidogenesis in nonpregnant mice. These findings suggest that pregnancy may suppress amyloidogenesis in mice. The suppression is caused by an anti-inflammatory effect of pregnancy. Estrogen and progesterone are probably unrelated to this finding.
对家族性地中海热淀粉样变性中妊娠对肾功能有害影响的观察表明，妊娠可能会增强淀粉样蛋白生成。为了确定妊娠是否确实会影响淀粉样蛋白生成，在怀孕后的不同时间给怀孕小鼠注射淀粉样蛋白增强因子（AEF）和硝酸银使其发生淀粉样变性，并用挤压涂片技术研究淀粉样蛋白沉积情况。通过在未怀孕雌性小鼠淀粉样蛋白诱导过程中给予外源性雌性激素（β-雌二醇和孕酮），研究了这些激素对淀粉样蛋白生成的可能影响。发现妊娠期间小鼠的淀粉样蛋白生成受到显著抑制。这种减少可能与妊娠对炎症刺激物（硝酸银）的影响有关，而不是对所注射的AEF的影响。外源性雌激素和孕酮未能抑制未怀孕小鼠的淀粉样蛋白生成。这些发现表明，妊娠可能会抑制小鼠的淀粉样蛋白生成。这种抑制是由妊娠的抗炎作用引起的。雌激素和孕酮可能与这一发现无关。
