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透明边缘角膜变性的治疗

Management of pellucid marginal corneal degeneration.

作者信息

Biswas S, Brahma A, Tromans C, Ridgway A

机构信息

Royal Eye Hospital, Manchester, UK.

出版信息

Eye (Lond). 2000 Aug;14 ( Pt 4):629-34. doi: 10.1038/eye.2000.155.

Abstract

PURPOSE

A retrospective study to ascertain the management of pellucid marginal corneal degeneration (PMCD).

METHOD AND RESULTS

Sixteen patients (average age 42.6 years) presented with PMCD. PMCD was bilateral in 13 and unilateral in 3 patients. Eight eyes underwent surgery. Nineteen eyes were managed non-surgically. Surgery involved corneal wedge excision (WE) (6 eyes), penetrating keratoplasty (PK) (3 eyes) and lamellar thermo-keratoplasty (LTK) (1 eye). Immediate pre-operative average visual acuity (VA) was 6/24, 6/10 and 6/60 with an average pre-operative astigmatism of 11.40 D, 9.75 D and 20.5 D for WE, PK and LTK respectively. After an average post-operative follow-up of 57 months, 66 months and 1 year, the average astigmatism was 8.90 D, 4.63 D and 6.00 D with an average final VA of 6/19, 6/15 and 6/6 for WE, PK and LTK respectively. In the nonsurgical group, at presentation, 40% of eyes had a VA of 6/12 or better. After an average follow-up period of 32.3 months, 80% of eyes had a visual acuity of 6/12 or better. Optical correction was achieved with spectacles and or contact lenses.

CONCLUSIONS

Surgical correction for PMCD provides poor long-term reduction of astigmatism. Patients with PMCD may be adequately corrected in the long term by the use of scleral fitted gas-permeable contact lenses.

摘要

目的

一项回顾性研究,以确定透明边缘角膜变性(PMCD)的治疗方法。

方法与结果

16例患者(平均年龄42.6岁)患有PMCD。13例为双侧发病,3例为单侧发病。8只眼接受了手术。19只眼采用非手术治疗。手术包括角膜楔形切除术(WE)(6只眼)、穿透性角膜移植术(PK)(3只眼)和板层热角膜成形术(LTK)(1只眼)。WE、PK和LTK术前平均视力(VA)分别为6/24、6/10和6/60,术前平均散光分别为11.40 D、9.75 D和20.5 D。术后平均随访57个月、66个月和1年,WE、PK和LTK的平均散光分别为8.90 D、4.63 D和6.00 D,最终平均视力分别为6/19、6/15和6/6。在非手术组中,就诊时40%的眼视力为6/12或更好。平均随访32.3个月后,80%的眼视力为6/12或更好。通过佩戴眼镜和/或隐形眼镜进行光学矫正。

结论

PMCD的手术矫正长期散光减少效果不佳。长期使用巩膜适配的透气隐形眼镜可使PMCD患者得到充分矫正。

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