Biswas S, Brahma A, Tromans C, Ridgway A
Royal Eye Hospital, Manchester, UK.
Eye (Lond). 2000 Aug;14 ( Pt 4):629-34. doi: 10.1038/eye.2000.155.
A retrospective study to ascertain the management of pellucid marginal corneal degeneration (PMCD).
Sixteen patients (average age 42.6 years) presented with PMCD. PMCD was bilateral in 13 and unilateral in 3 patients. Eight eyes underwent surgery. Nineteen eyes were managed non-surgically. Surgery involved corneal wedge excision (WE) (6 eyes), penetrating keratoplasty (PK) (3 eyes) and lamellar thermo-keratoplasty (LTK) (1 eye). Immediate pre-operative average visual acuity (VA) was 6/24, 6/10 and 6/60 with an average pre-operative astigmatism of 11.40 D, 9.75 D and 20.5 D for WE, PK and LTK respectively. After an average post-operative follow-up of 57 months, 66 months and 1 year, the average astigmatism was 8.90 D, 4.63 D and 6.00 D with an average final VA of 6/19, 6/15 and 6/6 for WE, PK and LTK respectively. In the nonsurgical group, at presentation, 40% of eyes had a VA of 6/12 or better. After an average follow-up period of 32.3 months, 80% of eyes had a visual acuity of 6/12 or better. Optical correction was achieved with spectacles and or contact lenses.
Surgical correction for PMCD provides poor long-term reduction of astigmatism. Patients with PMCD may be adequately corrected in the long term by the use of scleral fitted gas-permeable contact lenses.
一项回顾性研究,以确定透明边缘角膜变性(PMCD)的治疗方法。
16例患者(平均年龄42.6岁)患有PMCD。13例为双侧发病,3例为单侧发病。8只眼接受了手术。19只眼采用非手术治疗。手术包括角膜楔形切除术(WE)(6只眼)、穿透性角膜移植术(PK)(3只眼)和板层热角膜成形术(LTK)(1只眼)。WE、PK和LTK术前平均视力(VA)分别为6/24、6/10和6/60,术前平均散光分别为11.40 D、9.75 D和20.5 D。术后平均随访57个月、66个月和1年,WE、PK和LTK的平均散光分别为8.90 D、4.63 D和6.00 D,最终平均视力分别为6/19、6/15和6/6。在非手术组中,就诊时40%的眼视力为6/12或更好。平均随访32.3个月后,80%的眼视力为6/12或更好。通过佩戴眼镜和/或隐形眼镜进行光学矫正。
PMCD的手术矫正长期散光减少效果不佳。长期使用巩膜适配的透气隐形眼镜可使PMCD患者得到充分矫正。