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肾透析患者中的硬皮黏液水肿样皮肤疾病

Scleromyxoedema-like cutaneous diseases in renal-dialysis patients.

作者信息

Cowper S E, Robin H S, Steinberg S M, Su L D, Gupta S, LeBoit P E

出版信息

Lancet. 2000 Sep 16;356(9234):1000-1. doi: 10.1016/S0140-6736(00)02694-5.

Abstract

15 renal dialysis patients have been identified with a skin condition characterised by thickening and hardening of the skin of the extremities and an increase in dermal fibroblast-like cells associated with collagen remodelling and mucin deposition. The disease closely resembles scleromyxoedema, yet has significant enough clinical and histopathological differences to warrant its designation as a new clinicopathological entity.

摘要

已确定15名肾透析患者患有一种皮肤病,其特征为四肢皮肤增厚、硬化,与胶原重塑和黏蛋白沉积相关的真皮成纤维细胞样细胞增多。该疾病与硬化性黏液水肿极为相似,但在临床和组织病理学上存在足够显著的差异,足以将其认定为一种新的临床病理实体。

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