Gillery P, Maquart F X, Kalis B, Borel J P
C R Acad Sci III. 1986;303(3):59-64.
Skin fibroblasts from eight scleroderma patients were seeded in collagen lattices, and their capacity of retraction was compared to that of fibroblasts from normal volunteers. In all cases, pathological fibroblasts retracted collagen lattices earlier and more intensively than controls. This in vitro feature may be related to the cutaneous retraction which characterizes scleroderma lesions in vivo.
将8名硬皮病患者的皮肤成纤维细胞接种于胶原凝胶中，并将其收缩能力与正常志愿者的成纤维细胞进行比较。在所有病例中，病理性成纤维细胞比对照组更早且更强烈地收缩胶原凝胶。这种体外特征可能与硬皮病患者体内特征性的皮肤收缩有关。
