Lipsett M B
Cancer Res. 1975 Nov;35(11 Pt. 2):3359-61.
The effects of obesity on steroid metabolism in women with breast and uterine cancer have been considered. Obesity may increase plasma estrone by two mechanisms, a higher rate of secretion of the estrone precursor, androstenedione, and a higher rate of conversion of androstenedione to estrone. Obesity may alter routes of metabolism of androgens and estrogens. The excretion of specific urinary metabolites can therefore be altered by obesity alone. Thus, steroid indices of relative cancer risk or responsiveness must be constructed with due attention to obesity, one of many important variables.
肥胖对患有乳腺癌和子宫癌的女性类固醇代谢的影响已得到研究。肥胖可能通过两种机制增加血浆雌酮水平，一是雌酮前体雄烯二酮的分泌率更高，二是雄烯二酮向雌酮的转化率更高。肥胖可能改变雄激素和雌激素的代谢途径。因此，仅肥胖就可能改变特定尿液代谢物的排泄。所以，在构建相对癌症风险或反应性的类固醇指标时，必须充分考虑肥胖这一众多重要变量之一。
