Rao C V
Department of Obstetrics and Gynecology, University of Louisville Health Sciences Center, Louisville, Kentucky, USA.
Obstet Gynecol. 2000 Nov;96(5 Pt 1):783-6. doi: 10.1016/s0029-7844(00)00983-2.
Recent studies found that human and animal breast tissues and human breast cell lines contain low levels of receptors that bind hCG and its structural and functional homologue, LH. Those gonadotropins exert numerous anticancer effects in breast cancer models and cells, which might explain decreased breast cancer incidence in women who complete full-term pregnancies at a young age. The new findings also imply that premature chronic elevations of LH levels might contribute to decreased breast cancer incidence in women with early menopause, and elevated LH levels might contribute to a better prognosis after ovariectomy. Those findings predict that breast cancer risk might be reduced by early hCG treatment of women who plan to delay their first pregnancies; prophylactic hCG treatment might help women with family histories of breast cancer or oncogene mutations that predict breast cancer; and better prognoses might result when hCG is administered to breast cancer tissue.
最近的研究发现，人类和动物的乳腺组织以及人类乳腺细胞系含有低水平的能结合人绒毛膜促性腺激素（hCG）及其结构和功能同源物促黄体生成素（LH）的受体。这些促性腺激素在乳腺癌模型和细胞中发挥多种抗癌作用，这可能解释了年轻时完成足月妊娠的女性乳腺癌发病率降低的原因。新发现还表明，LH水平过早慢性升高可能导致早绝经女性乳腺癌发病率降低，而LH水平升高可能有助于卵巢切除术后的更好预后。这些发现预示，对于计划推迟首次怀孕的女性，早期给予hCG治疗可能降低乳腺癌风险；预防性hCG治疗可能有助于有乳腺癌家族史或预测乳腺癌的癌基因突变的女性；对乳腺癌组织给予hCG可能产生更好的预后。
