Kümmerer B M, Tautz N, Becher P, Thiel H, Meyers G
Federal Research Center for Virus Diseases of Animals, Paul-Ehrlich-Str. 28, D-72076, Tübingen, Germany.
Vet Microbiol. 2000 Nov 15;77(1-2):117-28. doi: 10.1016/s0378-1135(00)00268-6.
Two biotypes of pestiviruses, cytopathogenic (cp) and noncp viruses, can be distinguished by their effects on tissue culture cells. Identification of cp bovine viral diarrhea virus (BVDV) has been frequently reported since antigenically closely related noncp and cp BVDV can be isolated from cattle with fatal mucosal disease (MD) and are called a virus pair. In contrast to the BVDV system, only few cp border disease virus (BDV) and cp classical swine fever virus (CSFV) strains have been described. Serological analyses and sequence comparison studies showed that cp pestiviruses arise from noncp viruses by mutation. Elaborate studies during the last 10 years revealed that in most cases RNA recombination is responsible for the generation of the cp viruses. Recent results showed a second way for the development of a cp pestivirus which is based on the introduction of a set of point mutations within the NS2 gene.
瘟病毒的两种生物型，即细胞病变型（cp）和非细胞病变型病毒，可通过它们对组织培养细胞的作用加以区分。由于抗原性密切相关的非细胞病变型和细胞病变型牛病毒性腹泻病毒（BVDV）可从患有致命性黏膜病（MD）的牛中分离得到，并被称为病毒对，因此细胞病变型牛病毒性腹泻病毒（BVDV）的鉴定屡有报道。与BVDV系统不同，仅描述了少数细胞病变型边界病病毒（BDV）和细胞病变型经典猪瘟病毒（CSFV）毒株。血清学分析和序列比较研究表明，细胞病变型瘟病毒由非细胞病变型病毒通过突变产生。过去10年的详尽研究表明，在大多数情况下，RNA重组是细胞病变型病毒产生的原因。最近的结果显示了细胞病变型瘟病毒产生的另一种方式，该方式基于在NS2基因内引入一组点突变。
