为胞浆内单精子注射预先选择的少弱精子症男性减数分裂异常的发生率增加。
Increased incidence of meiotic anomalies in oligoasthenozoospermic males preselected for intracytoplasmic sperm injection.
作者信息
Egozcue S, Vendrell J M, Garcia F, Veiga A, Aran B, Barri P N, Egozcue J
机构信息
Unitat de Biologia Cellular, Universitat Autònoma de Barcelona, Spain.
出版信息
J Assist Reprod Genet. 2000 Jul;17(6):307-9. doi: 10.1023/a:1009444709504.
PURPOSE
Based on data from the literature, to detect the possible presence of an increased frequency of meiotic anomalies in oligoasthenozoospermic (OA) patients preselected for intracytoplasmic sperm injection.
METHODS
Meiotic studies in as many successive patients with a clinical indication for a diagnostic testicular biopsy as needed to complete at least 100 cases with a severe OA (motile sperm concentration < or = 1.5 x 10(6)/ml).
RESULTS
An increased incidence of meiotic anomalies was found in 102 patients with a severe OA (17.6%) compared to the mean for 105 patients with other etiologies in the series (5.7%) or the mean for patients reviewed in the literature (6.5%).
CONCLUSIONS
Patients with a severe OA have a higher incidence of synaptic anomalies. This may result in the malsegregation of chromosomes at meiosis I, producing abnormal sperm, and could explain the high incidence of sterility and some cases of abortion (in two thirds of the couples with abortions the husband had meiotic anomalies) in this group.
目的
基于文献数据，检测预先选定进行胞浆内单精子注射的少弱精子症（OA）患者中减数分裂异常频率可能增加的情况。
方法
对有诊断性睾丸活检临床指征的连续患者进行减数分裂研究，所需患者数量以完成至少100例严重少弱精子症（活动精子浓度≤1.5×10⁶/ml）病例为准。
结果
与该系列中105例其他病因患者的均值（5.7%）或文献中回顾的患者均值（6.5%）相比，102例严重少弱精子症患者中发现减数分裂异常的发生率增加（17.6%）。
结论
严重少弱精子症患者的联会异常发生率较高。这可能导致减数分裂I期染色体分离错误，产生异常精子，并且可以解释该组中不育症的高发生率以及一些流产病例（在三分之二的流产夫妇中，丈夫存在减数分裂异常）。
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