Lange R, Krause W, Engel W
Institut für Humangenetik der Universität Göttingen, Germany.
Hum Reprod. 1997 Oct;12(10):2154-8. doi: 10.1093/humrep/12.10.2154.
Between 1989 and 1992 meiotic chromosome studies and synaptonemal complex analyses were evaluated using light and, in part, electron microscopy in 46 infertile males with highly abnormal spermiograms. This examination focused on whether the breakdown of spermatogenesis could be attributed to pairing anomalies of bivalents. The study of meiotic chromosomes and synaptonemal complexes indicated normal spermatogenesis in five patients (11%); in the remainder, maturation arrest was diagnosed. In 21 individuals (50%) the breakdown was accompanied by pairing anomalies (asynapsis, fragmented synaptonemal complexes, X/Y univalence). Thus it is shown that male infertility can often partly be explained by meiotic disorders.
1989年至1992年间，对46名精子图谱高度异常的不育男性进行了减数分裂染色体研究和联会复合体分析，部分采用了光学显微镜，部分采用了电子显微镜。这项检查重点关注精子发生的障碍是否可归因于二价体的配对异常。减数分裂染色体和联会复合体的研究表明，5名患者（11%）精子发生正常；其余患者被诊断为成熟停滞。在21名个体（50%）中，精子发生障碍伴有配对异常（不联会、联会复合体片段化、X/Y单价体）。因此表明，男性不育症往往部分可由减数分裂障碍来解释。
