Pöhl M, Hohlagschwandtner M, Obruca A, Poschalko G, Weigert M, Feichtinger W
Institut for Assisted Reproduction, Vienna, Austria.
J Assist Reprod Genet. 2000 Jul;17(6):315-8. doi: 10.1023/a:1009448810413.
The purpose of the study was to evaluate whether number and size of antral follicles can predict the outcome of in vitro fertilization-embryo transfer.
A total of 113 patients were prospectively included into this study. After 19 days of down-regulation, number and size of follicles were determined by using recent three-dimensional transvaginal ultrasound technology. Before application of gonadotropin, all follicles had been defined as antral follicles. According to size, antral follicles were categorized into four different groups: group I included antral follicles < 5 mm, group II follicles 5-10 mm; group III 11-20 mm; and group IV > 20 mm. Pregnant and non-pregnant patients were compared in terms of their number of antral follicles of group I-IV. These four groups were then compared regarding implantation rate, number of retrieved oocytes, endometrium thickness, and age.
Pregnant patients showed an significant higher number of follicles with the size between 5 and 10 mm (P = 0.04). A significant correlation was found between number of retrieved oocytes and antral follicle size of 5-10 mm (P = 0.0001). Antral follicles with a diameter between 5 and 10 mm decreased significantly with age (P = 0.008). In group III and IV, a significant correlation was found between antral follicle size (P = 0.016) and serum estradiol level after gonadotropin-releasing hormone-agonist down-regulation (P = 0.011).
We demonstrated that patients with a higher number of follicles between 5 and 10 mm showed a significantly higher pregnancy rate, whereas patients with a dominant number of antral follicles > 11 mm have a higher cancellation rate due to ovarian low response.
本研究旨在评估窦卵泡的数量和大小是否能够预测体外受精-胚胎移植的结局。
共有113例患者前瞻性纳入本研究。在进行19天的降调节后，采用最新的三维经阴道超声技术测定卵泡的数量和大小。在应用促性腺激素之前，所有卵泡均被定义为窦卵泡。根据大小，将窦卵泡分为4个不同组：I组包括直径<5mm的窦卵泡，II组为5-10mm的卵泡；III组为11-20mm；IV组>20mm。比较妊娠和未妊娠患者I-IV组窦卵泡的数量。然后比较这四组的种植率、取卵数、子宫内膜厚度和年龄。
妊娠患者5-10mm大小的卵泡数量显著更多（P=0.04）。取卵数与5-10mm的窦卵泡大小之间存在显著相关性（P=0.0001）。直径5-10mm的窦卵泡数量随年龄显著减少（P=0.008）。在III组和IV组中，发现窦卵泡大小（P=0.016）与促性腺激素释放激素激动剂降调节后的血清雌二醇水平之间存在显著相关性（P=0.011）。
我们证明，5-10mm卵泡数量较多的患者妊娠率显著更高，而优势窦卵泡>11mm的患者因卵巢低反应取消率更高。
