Frattarelli John L, Levi Andrew J, Miller Bradley T, Segars James H
Tripler Army Medical Center, Honolulu, Hawaii 96859-5000, USA.
Fertil Steril. 2003 Aug;80(2):350-5. doi: 10.1016/s0015-0282(03)00664-2.
To determine the predictive value and define threshold values for basal antral follicle count in patients undergoing IVF.
Prospective cohort analysis. Tertiary care center. Two hundred eighty-nine patients. Transvaginal ultrasonography before starting gonadotropin administration.
Number of oocytes retrieved, basal hormone levels, and cycle outcomes.
Pregnant patients had significantly more antral follicles (13.8 +/- 7.5 vs. 12.4 +/- 10.0). Patients in whom cycles were canceled had significantly fewer antral follicles (7.6 +/- 4.8 vs. 13.7 +/- 8.8). Antral follicle count significantly correlated with most prestimulation and poststimulation IVF variables. Threshold analysis demonstrated a lower pregnancy rate (23.5% vs. 57.6%) and a higher cancellation rate (41% vs. 6.4%) associated with having four or fewer antral follicles.
CONCLUSION(S): The basal antral follicle count identified patients who responded poorly to IVF stimulation. Having four or fewer antral follicles was associated with a high cancellation rate (41%) and, in patients without a cancelled cycle, a low pregnancy rate (23%). However, no antral follicle count absolutely predicted pregnancy or cycle cancellation.
确定基础窦卵泡计数对接受体外受精（IVF）患者的预测价值并定义阈值。
前瞻性队列分析。三级医疗中心。289例患者。在开始促性腺激素给药前进行经阴道超声检查。
获卵数、基础激素水平和周期结局。
妊娠患者的窦卵泡显著更多（13.8±7.5对12.4±10.0）。周期取消的患者窦卵泡显著更少（7.6±4.8对13.7±8.8）。窦卵泡计数与大多数刺激前和刺激后的IVF变量显著相关。阈值分析表明，窦卵泡数为4个或更少时，妊娠率较低（23.5%对57.6%），取消率较高（41%对6.4%）。
基础窦卵泡计数可识别对IVF刺激反应不良的患者。窦卵泡数为4个或更少与高取消率（41%）相关，在未取消周期的患者中，妊娠率较低（23%）。然而，没有任何窦卵泡计数能绝对预测妊娠或周期取消。
