Chelyshev Iu A, Saĭtkulov K I
Kazan State Medical University.
Usp Fiziol Nauk. 2000 Jul-Sep;31(3):54-69.
The Schwann cell is one of the major cell types in vertebrate peripheral nervous system. The Schwann cell precursors are derived from the neural crest and migrate along the growing axons towards their ultimate localization. Recently obtained data regarding expression of different molecules (S100 protein, myelin proteins, low-affinity nerve growth factor receptor, GAP-43, adhesion molecules) and particularly transcription factors SCIP and Krox-20 allowed to precisely characterize lineage for myelinating and non myelinating Schwann cells and their phenotypes. The special attention to communication between neurones and Schwann cells is paid. The advance in study of the biology of Schwann cell is of great practical importance for understanding the molecular basis of neuropathies and posttraumatic peripheral nerve regeneration. Schwann cells are also considered as intriguously perspective candidates for transplantation into CNS to stimulate regeneration of axons in brain and spinal cord.
施万细胞是脊椎动物外周神经系统中的主要细胞类型之一。施万细胞前体起源于神经嵴，并沿着生长中的轴突迁移至其最终定位。最近获得的有关不同分子（S100蛋白、髓磷脂蛋白、低亲和力神经生长因子受体、GAP-43、黏附分子）表达的数据，尤其是转录因子SCIP和Krox-20，使得能够精确地描述有髓鞘和无髓鞘施万细胞及其表型的谱系。人们对神经元与施万细胞之间的通讯给予了特别关注。施万细胞生物学研究的进展对于理解神经病变和创伤后外周神经再生的分子基础具有重要的实际意义。施万细胞也被认为是移植到中枢神经系统以刺激脑和脊髓轴突再生的极具前景的候选细胞。
