Böttner A, de Jong A, Schmid P, Schüller S, Traeder W, Weiskopf S
Bundesverband für Tiergesundheit e. V., Bonn.
Berl Munch Tierarztl Wochenschr. 2000 Sep;113(9):344-7.
This article describes the meaning of the term clinical breakpoint. This is followed by a discussion of the parameters that need to be considered when setting valid breakpoints for active substances in veterinary medicine; in doing so we closely follow equivalent regulations and guidelines on the establishment of breakpoints in human medicine. Along with pharmacokinetic data and the results of clinical efficacy tests, susceptibility data of relevant organisms play a key role in the establishment of breakpoints. Published breakpoints are currently only available for a few modern drugs in veterinary medicine.
本文描述了临床断点这一术语的含义。接下来讨论在为兽药中的活性物质设定有效断点时需要考虑的参数；在此过程中，我们严格遵循人类医学中关于断点设定的等效法规和指南。除了药代动力学数据和临床疗效测试结果外，相关生物体的药敏数据在断点设定中也起着关键作用。目前，已公布的断点仅适用于兽药中的少数现代药物。
