Kietzmann Manfred, Böttner Alexander, Hafez H Mohamed, Kehrenberg Corinna, Klarmann Dieter, Krabisch Peter, Kühn Tilman, Luhofer Gabriele, Richter Angelika, Schwarz Stefan, Traeder Wolfgang, Waldmann Karl-Heinz, Wallmann Jürgen, Werckenthin Christiane
Institut für Pharmakologie,Toxikologie und Pharmazie, Tierärztliche Hochschule Hannover.
Berl Munch Tierarztl Wochenschr. 2004 Mar-Apr;117(3-4):81-7.
In vitro susceptibility tests are performed to receive information for selecting the most suitable antibacterial agent. As result of in vitro susceptibility tests, the minimum inhibitory concentration (MIC) indicates bacteria as resistant or sensitive. To determine MIC, therapeutically relevant breakpoints have to be defined. Microbiological criteria, chemical and physical characteristics as well as pharmacokinetic and toxicological (tolerance) properties of the antimicrobial compounds have to be considered in the selection of the therapeutic agent in addition to clinical experiences. Using some concentration and time dependent antibiotics as examples, it is demonstrated that the above mentioned criteria are not sufficiently considered in currently defined breakpoints.
进行体外药敏试验以获取信息，用于选择最合适的抗菌剂。作为体外药敏试验的结果，最低抑菌浓度（MIC）表明细菌耐药或敏感。为了确定MIC，必须定义治疗相关的断点。除临床经验外，在选择治疗药物时还必须考虑抗菌化合物的微生物学标准、化学和物理特性以及药代动力学和毒理学（耐受性）特性。以一些浓度和时间依赖性抗生素为例，证明目前定义的断点中没有充分考虑上述标准。
