Eskay R L, Warberg J, Mical R S, Porter J C
Endocrinology. 1975 Oct;97(4):816-24. doi: 10.1210/endo-97-4-816.
Prostaglandin E2 (PGE2) was infused into a lateral ventricle of adult male rats or infused into a hypophysial portal vessel. Intraventricularly administered PGE2 stimulated the release of LH, FSH, and prolactin but not TSH. Intraventricular infusion of the control solution did not alter the basal release of any of these hormones. PGE2 was found to be a potent stimulator of LH release, but larger quantities were needed to stimulate the release of FSH or prolactin. In addition, lateral ventricle infusion of 5 mug or 20 mug of PGE2 stimulated a 2- to 3-fold increase in the concentration of LHRH in hypophysial portal plasma but did not affect LHRH levels in arterial plasma. PGE2 infused into a hypophysial portal vessel at a rate of 0.167 mug/min for 30 min, or infusion of the control solution, resulted in similar changes in the concentration of FSH, LH, and prolactin in arterial plasma. The results of this investigation suggest that PGE2 stimulates the release of gonadotropins in vivo by enhancing the release of LHRH. The portal vessel infusion studies do not support a direct stimulatory effect of PGE2 on the pituitary gonadotrophs.
将前列腺素E2（PGE2）注入成年雄性大鼠的侧脑室或注入垂体门脉血管。脑室内注射PGE2可刺激促黄体生成素（LH）、促卵泡生成素（FSH）和催乳素的释放，但不刺激促甲状腺激素（TSH）的释放。脑室内注入对照溶液不会改变这些激素的基础释放量。发现PGE2是LH释放的有效刺激剂，但刺激FSH或催乳素的释放需要更大的量。此外，向侧脑室注入5微克或20微克的PGE2可刺激垂体门脉血浆中促性腺激素释放激素（LHRH）浓度增加2至3倍，但不影响动脉血浆中LHRH的水平。以0.167微克/分钟的速率向垂体门脉血管注入PGE2 30分钟，或注入对照溶液，导致动脉血浆中FSH、LH和催乳素浓度发生类似变化。本研究结果表明，PGE2通过增强LHRH的释放来刺激体内促性腺激素的释放。门脉血管注入研究不支持PGE2对垂体促性腺细胞有直接刺激作用。
