Nir I, Schmidt U, Zilber N
Department of Pharmacology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
J Neural Transm Gen Sect. 1994;95(3):173-7. doi: 10.1007/BF01271564.
PGE2 was shown to play an essential role in the gonado-inhibiting effect of melatonin in Syrian hamsters by transforming the neuroendocrine signal to gonadal reactivity. Prostaglandin is a vital link in the transduction of photoperiodic information into gonadal function and the difference in its levels brought about by melatonin given at different times of the day could explain the phenomenon why gonadal involution occurs only upon administration of melatonin towards the end of the day. It appears also that the melatonin signal is decoded in the pituitary, probably involving the short loop negative feedback of LH on LH-RH hormones.
前列腺素E2（PGE2）通过将神经内分泌信号转化为性腺反应性，在叙利亚仓鼠褪黑素的性腺抑制作用中发挥重要作用。前列腺素是将光周期信息转化为性腺功能的关键环节，而一天中不同时间给予褪黑素所导致的其水平差异，可以解释为什么只有在一天快结束时给予褪黑素才会出现性腺退化的现象。似乎褪黑素信号在垂体中被解码，可能涉及促黄体生成素（LH）对促性腺激素释放激素（LH-RH）的短环负反馈。
