Pardutz A, Krizbai I, Multon S, Vecsei L, Schoenen J
Department of Neurology, University of Szeged, Hungary.
Neuroreport. 2000 Sep 28;11(14):3071-5. doi: 10.1097/00001756-200009280-00008.
Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraineurs a delayed attack of unknown mechanisms. Subcutaneous nitroglycerin (10 mg/kg) produced a significant increase of nitric oxide synthase (NOS)- and c-fos-immunoreactive neurons in the cervical part of trigeminal nucleus caudalis in rats after 4 h. This effect was not observed in the thoracic dorsal horn. Similar increase of NOS and c-fos was obtained in the brain stem after a somatic nociceptive stimulus, i.e. on the side of the formalin injection in the lip. Nitric oxide is thus able to increase NOS availability in second order nociceptive trigeminal neurons, which may be relevant for central sensitization and the understanding of its effect in migraine.
一氧化氮供体硝酸甘油的全身给药会在偏头痛患者中引发机制不明的延迟性发作。皮下注射硝酸甘油（10毫克/千克）4小时后，大鼠三叉神经脊束核颈部的一氧化氮合酶（NOS）和c-fos免疫反应性神经元显著增加。在胸段背角未观察到这种效应。在躯体伤害性刺激后，即在唇部注射福尔马林的一侧，脑干中也出现了类似的NOS和c-fos增加。因此，一氧化氮能够增加二级伤害性三叉神经元中的NOS可用性，这可能与中枢敏化及其在偏头痛中的作用理解有关。
