Knyihár-Csillik E, Toldi J, Mihály A, Krisztin-Péva B, Chadaide Z, Németh H, Fenyo R, Vécsei L
Department of Neurology, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary.
J Neural Transm (Vienna). 2007;114(4):417-21. doi: 10.1007/s00702-006-0545-z. Epub 2006 Aug 10.
Nitroglycerin, often used as a migraine model, results in increased number of c-fos immunoreactive secondary sensory neurons in the caudal trigeminal nucleus. Since synapses between first- and second-order trigeminal neurons are mediated by excitatory amino acids, NMDA receptors are presumably inhibited by kynurenic acid, the only known endogeneous NMDA receptor antagonist. Although kynurenic acid does not cross the BBB, its precursor, kynurenine, if combined with probenecid, crosses it readily. Systemic kynurenine + probenecid treatment significantly diminishes nitroglycerin-induced increase of c-fos immunoreactivity in the brainstem.
硝酸甘油常被用作偏头痛模型，它会导致尾侧三叉神经核中c-fos免疫反应性二级感觉神经元数量增加。由于一级和二级三叉神经元之间的突触由兴奋性氨基酸介导，NMDA受体大概会被犬尿喹啉酸抑制，犬尿喹啉酸是唯一已知的内源性NMDA受体拮抗剂。尽管犬尿喹啉酸不能穿过血脑屏障，但其前体犬尿氨酸若与丙磺舒结合，则能轻易穿过血脑屏障。全身性给予犬尿氨酸+丙磺舒治疗可显著减少硝酸甘油诱导的脑干中c-fos免疫反应性增加。
