滤泡基质细胞和淋巴细胞归巢至滤泡。

Follicular stromal cells and lymphocyte homing to follicles.

作者信息

Cyster J G, Ansel K M, Reif K, Ekland E H, Hyman P L, Tang H L, Luther S A, Ngo V N

机构信息

Department of Microbiology and Immunology, University of California San Francisco, 94143-0414, USA.

出版信息

Immunol Rev. 2000 Aug;176:181-93. doi: 10.1034/j.1600-065x.2000.00618.x.

DOI:10.1034/j.1600-065x.2000.00618.x

PMID:11043777

Abstract

Follicular dendritic cells (FDCs), the best defined stromal cell subset within lymphoid follicles, play a critical role in presenting intact antigen to B lymphocytes. The discovery that many follicular stromal cells make B-lymphocyte chemoattractant (BLC), a CXC chemokine that attracts CXCR5+ cells, provides a basis for understanding how motile B cells come into contact with stationary FDCs. Here we review our work on BLC and discuss properties of BLC-expressing follicular stromal cells. We also review the properties of primary follicle and germinal center FDCs and suggest a model of FDC development that incorporates information about BLC expression. Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles.

摘要

滤泡树突状细胞（FDCs）是淋巴滤泡中定义最明确的基质细胞亚群，在向B淋巴细胞呈递完整抗原方面发挥着关键作用。许多滤泡基质细胞可产生B淋巴细胞趋化因子（BLC），这是一种吸引CXCR5 +细胞的CXC趋化因子，这一发现为理解运动性B细胞如何与静止的FDCs接触提供了基础。在此，我们回顾了我们关于BLC的研究工作，并讨论了表达BLC的滤泡基质细胞的特性。我们还回顾了初级滤泡和生发中心FDCs的特性，并提出了一个整合了BLC表达信息的FDC发育模型。最后，我们考虑抗原识别如何导致T和B淋巴细胞的趋化因子反应性发生变化，这可能有助于指导它们进出淋巴滤泡的运动。