Department of Laboratory Medicine, West China Second University Hospital, and Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, No. 20, Section 3, Renmin Road South, Chengdu, 610041, Sichuan, People's Republic of China.
State Key Laboratory of Biotherapy and Cancer Center/National Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, People's Republic of China.
Clin Exp Med. 2024 Oct 24;24(1):244. doi: 10.1007/s10238-024-01508-8.
CXCL13 is a chemokine that plays an important role in the regulation and development of secondary lymphoid organs. CXCL13 is also involved in the regulation of pathological processes, particularly inflammatory responses, of many diseases. The function of CXCL13 varies depending on the condition of the host. In a healthy condition, CXCL13 is mainly secreted by mouse stromal cells or human follicular helper T cells, whereas in diseases conditions, they are produced by human peripheral helper T cells and macrophages in non-lymphoid tissues; this is termed ectopic expression of CXCL13. Ectopic CXCL13 expression is involved in the pathogenesis of various immune-mediated inflammatory diseases as it regulates the migration of B lymphocytes, T lymphocytes, and other immune cells in inflammatory sites as well as influences the expression of inflammatory factors. Additionally, ectopic expression of CXCL13 plays a key role in ectopic lymphoid organ formation. In this review, we focused on the sources of CXCL13 in different conditions and its regulatory mechanisms in immune-mediated inflammatory diseases, providing novel ideas for further research on targeting CXCL13 for the treatment of immune-mediated inflammatory diseases.
趋化因子（C-X-C 基序）配体 13（CXCL13）是一种在次级淋巴器官的调节和发育中起重要作用的趋化因子。CXCL13 还参与许多疾病的病理过程的调节，特别是炎症反应。CXCL13 的功能因宿主的状况而异。在健康状态下，CXCL13 主要由小鼠基质细胞或人类滤泡辅助 T 细胞分泌，而在疾病状态下，它由人类外周辅助 T 细胞和非淋巴组织中的巨噬细胞产生；这被称为 CXCL13 的异位表达。异位 CXCL13 表达参与各种免疫介导的炎症性疾病的发病机制，因为它调节炎症部位 B 淋巴细胞、T 淋巴细胞和其他免疫细胞的迁移，并影响炎症因子的表达。此外，异位表达的 CXCL13 在异位淋巴器官形成中起关键作用。在这篇综述中，我们重点关注了不同条件下 CXCL13 的来源及其在免疫介导的炎症性疾病中的调节机制，为靶向 CXCL13 治疗免疫介导的炎症性疾病的进一步研究提供了新的思路。
