Bigatti M P, Ardito G, Lamberti L, Crovella S, Collell M, Giordanino S, Benso L
Department of Animal and Human Biology, Torino University, Italy.
Neoplasma. 2000;47(4):234-8.
Chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and high frequency cells (HFCs) have been assessed in peripheral blood lymphocytes of 10 neurofibromatosis (NF1) patients and 10 healthy controls. In both groups, the spontaneous rates and the induced (bleomycin for CA and MMC for SCE) frequencies were analyzed. No differences between cells from NF1 patients and controls were observed with respect to spontaneous or bleomycin induced CA. Spontaneous or MMC induced SCE frequencies were also similar in NF1 patients and controls. HFCs, on the contrary, were statistically lower in NF1 patients.
已对10例神经纤维瘤病（NF1）患者和10名健康对照者外周血淋巴细胞中的染色体畸变（CA）、姐妹染色单体交换（SCE）和高频细胞（HFC）进行了评估。在两组中，分析了自发率和诱导率（博来霉素诱导CA，丝裂霉素诱导SCE）。在自发或博来霉素诱导的CA方面，未观察到NF1患者和对照者细胞之间存在差异。NF1患者和对照者的自发或丝裂霉素诱导的SCE频率也相似。相反，NF1患者的HFC在统计学上较低。
