Wu Y Q
Zhonghua Zhong Liu Za Zhi. 1986 Jan;8(1):23-5.
The spontaneous and mitomycin-c (MMC) induced sister chromatid exchanges (SCE) and chromosome aberrations in cultured lymphocytes from members of "high risk" and "low risk" esophageal cancer families in Linxian County were studied. The results showed that the frequencies of the spontaneous SCE of "high risk" and "low risk" esophageal cancer groups were 7.8 +/- 0.25 and 8.3 +/- 0.25/per cell. There were no difference between these two groups (P greater than 0.5). The frequencies of the SCE induced by MMC in "high risk" and "low risk" esophageal cancer groups were 43.8 +/- 2.4 and 21.6 +/- 1.1/per cell. There were noteworthy difference (P less than 0.001). However, the frequencies of the spontaneous and MMC induced chromosome aberrations in "high risk" cancer families were higher than those of the "low risk" ones.
对河南省林县“高危”和“低危”食管癌家族成员培养淋巴细胞的自发及丝裂霉素 - c（MMC）诱导的姐妹染色单体交换（SCE）和染色体畸变进行了研究。结果显示，“高危”和“低危”食管癌组的自发SCE频率分别为7.8±0.25和8.3±0.25/细胞。两组之间无差异（P＞0.5）。MMC诱导的“高危”和“低危”食管癌组的SCE频率分别为43.8±2.4和21.6±1.1/细胞。存在显著差异（P＜0.001）。然而，“高危”癌家族中自发及MMC诱导的染色体畸变频率高于“低危”家族。
