Ty1病毒样颗粒中的基因组RNA是二聚体。
The genomic RNA in Ty1 virus-like particles is dimeric.
作者信息
Feng Y X, Moore S P, Garfinkel D J, Rein A
机构信息
HIV Drug Resistance Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.
出版信息
J Virol. 2000 Nov;74(22):10819-21. doi: 10.1128/jvi.74.22.10819-10821.2000.
Abstract
The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized during the proteolytic maturation of the particle. The stabilization of the dimer suggests that one of the cleavage products of TyA1 possesses nucleic acid chaperone activity.
摘要
酵母逆转座子Ty1在许多重要方面与逆转录病毒相似，但也表现出与它们的一些根本差异。我们现在报告，与逆转录病毒一样，Ty1病毒样颗粒中的基因组RNA是二聚体。Ty1二聚体也类似于逆转录病毒二聚体，因为它们在颗粒的蛋白水解成熟过程中得到稳定。二聚体的稳定表明TyA1的一种裂解产物具有核酸伴侣活性。
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